研究業績 ~Publications~


Oyama K, Hori Y, Mimura K, Nagai Y, Eldridge MAG, Saunders RC, Miyakawa N, Hirabayashi T, Inoue K, Suhara T, Takada M, Higuchi M, Richmond BJ, Minamimoto T.(2022) Chemogenetic disconnection between the orbitofrontal cortex and the rostromedial caudate nucleus disrupts motivational control of goal-directed action. The Journal of Neuroscience, 42(32):6267-6275.

Ninomiya T, Nakagawa H, Inoue K, Nishimura Y, Oishi T, Yamashita T, Takada M.(2022) Origin of multisynaptic corticospinal pathway to forelimb segments in macaques and its reorganization after spinal cord injury. Frontiers in Neural Circuits, 16:847100.

Inagaki M, Inoue K, Tanabe S, Kimura K, Takada M, Fujita I.(2022) Rapid processing of threatening faces in the amygdala of non-human primates: subcortical inputs and dual roles. Cerebral Cortex, bhac109.

Miyajima K, Sudo Y, Sanechika S, Hara Y, Horiguchi M, Xu F, Suzuki M, Hara S, Tanda K, Inoue K, Takada M, Yoshioka N, Takebayashi H, Mori-Kojima M, Sugimoto M, Sumi-Ichinose C, Kondo K, Takao K, Miyakawa T, Ichinose H.(2022) Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin. Journal of Neurochemistry, 161(2):129-145.

Niu M, Kasai A, Tanuma M, Seiriki K, Igarashi H, Kuwaki T, Nagayasu K, Miyaji K, Ueno H, Tanabe W, Seo K, Yokoyama R, Ohkubo J, Ago Y, Hayashida M, Inoue K, Takada M, Yamaguchi S, Nakazawa T, Kaneko S, Okuno H, Yamanaka A, Hashimoto H.(2022) Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses. Science Advances, 8(11):eabi6375.

Oyama K, Hori Y, Nagai Y, Miyakawa N, Mimura K, Hirabayashi T, Inoue K, Takada M, Higuchi M, Minamimoto T.(2022) Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaques. The Journal of Neuroscience, 42(12):2552-2561.

Suzuki M, Inoue K, Nakagawa H, Ishida H, Kobayashi K, Isa T, Takada M, Nishimura Y.(2022) A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys. The Journal of Physiology, 600(7):1731-1752.

Ogata K, Kadono F, Hirai Y, Inoue K, Takada M, Karube F, Fujiyama F.(2022) Conservation of the direct and indirect pathways dichotomy in mouse caudal striatum with uneven distribution of dopamine receptor D1- and D2-expressing neurons. Frontiers in Neuroanatomy, 16:809446.


Ohara S, Yoshino R, Kimura K, Kawamura T, Tanabe S, Zheng A, Nakamura S, Inoue K, Takada M, Tsutsui K-I, Witter MP.(2021) Laminar organization of the entorhinal cortex in macaque monkeys based on cell-type-specific markers and connectivity. Frontiers in Neural Circuits, 15:790116.

Kudo M, Wupuer S, Fujiwara M, Saito Y, Kubota S, Inoue K, Takada M, Seki K.(2021) Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intranerve injection of adeno-associated virus 6 vector. Molecular Therapy - Methods & Clinical Development, 23:11-22.

Hirabayashi T, Nagai Y, Hori Y, Inoue K, Aoki I, Takada M, Suhara T, Higuchi M, Minamimoto T.(2021) Chemogenetic sensory fMRI reveals behaviorally-relevant bidirectional changes in primate somatosensory network. Neuron, 109(20):3312-3322.

Mimura K, Nagai Y, Inoue K, Matsumoto J, Hori Y, Sato C, Kimura K, Okauchi T, Hirabayashi T, Nishijo H, Yahata N, Takada M, Suhara T, Higuchi M, Minamimoto T.(2021) Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets. iScience, 24(9):103066.

Oguchi M, Jiasen J, Yoshioka TW, Tanaka YR, Inoue K, Takada M, Kikusui T, Nomoto K, Sakagami M.(2021) Microendoscopic calcium imaging of the primary visual cortex of behaving macaques. Scientific Reports, 11:17021.

Hori Y, Mimura K, Nagai Y, Fujimoto A, Oyama K, Kikuchi E, Inoue K, Takada M, Suhara T, Richmond BJ, Minamimoto T.(2021) Single caudate neurons encode temporally discounted value for formulating motivation for action. eLife, 10:e61248.

Chiken S, Takada M, Nambu A.(2021) Altered dynamic information flow through the cortico-basal ganglia pathways mediates Parkinson’s disease symptoms. Cerebral Cortex, 31(12):5363-5380.

Otsuka Y, Tsuge H, Uezono S, Tanabe S, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M.(2021) Retrograde Transgene Expression via Neuron-Specific Lentiviral Vector Depends on Both Species and Input Projection. Viruses, 13(7):1387.

Yamanaka H, Takata Y, Nakagawa H, Isosaka-Yamanaka T, Yamashita T, Takada M.(2021) An enhanced therapeutic effect of repetitive transcranial magnetic stimulation combined with antibody treatment in a primate model of spinal cord injury. PLoS ONE, 16(6):e0252023.

Oyama K, Hori Y, Nagai Y, Miyakawa N, Mimura K, Hirabayashi T, Inoue K, Suhara T, Takada M, Higuchi M, Minamimoto T.(2021) Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making. Science Adv, 26(7):eabg4246.

Suzuki TW, Inoue K, Takada M, Tanaka M.(2021) Effects of optogenetic suppression of cortical input on primate thalamic neuronal activity during goal-directed behavior. eNeuro, 8:511-520.

Takata Y, Nakagawa H, Ninomiya T, Yamanaka H, Takada M.(2021) Morphological features of large layer V pyramidal neurons in cortical motor-related areas of macaque monkeys: analysis of basal dendrites. Sci Rep, 11:4171.

Labuguen RT, Matsumoto J, Negrete SB, Nishimaru H, Nishijo H, Takada M, Go Y, Inoue K, Shibata T.(2021) MacaquePose: a novel ‘in the wild’ macaque monkey pose dataset for markerless motion capture. Front Behav Neurosci, 14:581154.


Tremblay S, et al.(2020) An open resource for non-human primate optogenetics. Neuron, 108:1075-1090.

Ueno M, Nakamura Y, Nakagawa H, Niehaus JK, Maezawa M, Gu Z, Kumanogoh A, Takebayashi H, Lu QR, Takada M, Yoshida Y (2020) Olig2-induced semaphorin expression drives corticospinal axon retraction after spinal cord injury. Cereb Cortex, 30:5702-5716.

Maeda K, Inoue K, Kunimatsu J, Takada M, Hikosaka O (2020) Primate amygdalo-nigral pathway for boosting oculomotor action in motivating situations. iScience, 23:101194.

Nagai Y, Inoue K, Takada M, Minamimoto T, et al. (2020) Deschloroclozapine: a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nat Neurosci,23:1157-1167.

Amita H, Kim H, Inoue K, Takada M, Hikosaka O (2020) Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift. Nat Commun, 11:1876.

Lu X, Inoue KI, Ohmae S, Uchida Y (2020) New Cerebello-Cortical Pathway Involved in Higher-Order Oculomotor Control. Cerebellum, 19:401-408.


Kikuta S, Iguchi Y, Kakizaki T, Kobayashi K, Yanagawa Y, Takada M, Osanai M (2019) Store-operated calcium channels are involved in spontaneous slow calcium oscillations in striatal neurons. Front Cell Neurosci, 13:547.

Ninomiya T, Inoue K, Hoshi E, Takada M (2019) Layer specificity of inputs from supplementary motor area and dorsal premotor cortex to primary motor cortex in macaque monkeys. Sci Rep, 9:18230.

Kubota S, Sidikejiang W, Kudo M, Inoue K, Umeda T, Takada M, Seki K (2019) Optogenetic recruitment of spinal reflex pathways from 1 large-diameter primary afferents in non-transgenic rats transduced with AAV9/Channelrhodopsin 2. J Physiol, 597:5025-5040.

Murakami J, Tachibana Y, Akiyama S, Kato T, Taniguchi A, Nakajima Y, Shimoda M, Kano Y, Takada M, Nambu A, Yoshida A (2019) Oral splint ameliorates tic symptoms in patients with tourette syndrome. Movement Disorders, 34:1577-1578.

Nagai Y, Nishitani N, Yasuda M, Ueda Y, Fukui Y, Andoh C, Shirakawa H, Nakagawa T, Inoue K, Nagayasu K, Kasparov S, Nakamura K, Kaneko S (2019) Identification of neuron-type specific promoters in monkey genome and their functional validation in mice. Biochem Biophys Res Commun., 518:619-624.

Kawai T, Yamada H, Sato N, Takada M, Matsumoto M (2019) Preferential representation of past outcome information and future choice behavior by putative inhibitory interneurons rather than putative pyramidal neurons in the primate dorsal anterior cingulate cortex. Cereb Cortex, 29:2339-2352.

Tanabe S, Uezono S, Tsuge H, Fujiwara M, Miwa M, Kato S, Nakamura K, Kobayashi K, Inoue K, Takada M (2019) A note on retrograde gene transfer efficiency and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins. Scientific Reports, 9:3567.

Nakagawa H, Ninomiya T, Yamashita T, Takada M (2019) Treatment With the Neutralizing Antibody Against Repulsive Guidance Molecule-a Promotes Recovery From Impaired Manual Dexterity in a Primate Model of Spinal Cord Injury. Cereb Cortex, 29:561-572.

Inoue K, Miyachi S, Nishi K, Okado H, Nagai Y, Minamimoto T, Nambu A, Takada M (2019) Recruitment of calbindin into nigral dopamine neurons protects against MPTP-induced parkinsonism. Movement Disorders, 34:200-209.

Kato S, Sugawara M, Kobayashi K, Kimura K, Inoue K, Takada M, Kobayashi K (2019) Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E. J Neurosci Methods, 311:147-155.

Ironside M, Amemori K, McGrath CL, Pedersen ML, Kang MS, Amemori S, Frank MJ, Graybiel AM, Pizzagalli DA (2019) Approach-avoidance conflict in major depression: Congruent neural findings in human and non-human primates. Biological Psychiatry, 87:399-408

Amemori S, Amemori K, Yoshida T, Papageorgiou GK, Xu R, Shimazu H, Desimone R, Graybiel AM (2019) Microstimulation of primate neocortex targeting striosomes induces negative decision-making. European Journal of Neuroscience, 51:731-741

Hong S, Amemori S, Chung E, Gibson DJ, Amemori K, Graybiel AM (2019) Predominant striatal input to the lateral habenula in macaques comes from striosome. Current Biology, 29:51-61.

Hikosaka O, Kim HF, Amita H, Yasuda M, Isoda M, Tachibana Y, Yoshida A (2019) Direct and indirect pathways for choosing objects and actions. Eur J Neurosci, 49:637-645.

Amita H, Kim HF, Smith M, Gopal A, Hikosaka O (2019) Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia. Eur J Neurosci, 49:712-725.

Amita H, Hikosaka O (2019) Indirect pathway from caudate tail mediates rejection of bad objects in periphery. Sci Adv, 5:8.

Hikosaka O., Yasuda M., Nakamura K., Isoda M., Kim HF., Terao Y., Amita H., Maeda K (2019) Multiple neuronal circuits for variable object?action choices based on short- and long-term memories. Proc Natl Acad Sci USA, 23:26313-26320


Ogasawara T, Nejime M, Takada M, Matsumoto M (2018) Primate Nigrostriatal Dopamine System Regulates Saccadic Response Inhibition. Neuron, 100:1513-1526.

Xu C, Li Q, Efimova O, He L, Tatsumoto S, Stepanova V, Oishi T, Udono T, Yamaguchi K, Shigenobu S, Kakita A, Nawa H, Khaitovich P, Go Y (2018) Human-specific features of spatial gene expression and regulation in eight brain regions. Genome Res, 28:1097-1110.

Koga A, Tanabe H, Hirai Y, Imai H, Imamura M, Oishi T, Stanyon R, Hirai H (2018) Co-Opted Megasatellite DNA Drives Evolution of Secondary Night Vision in Azara's Owl Monkey. Genome Biol Evol, 9:1963-1970.

Higo N, Sato A, Yamamoto T, Oishi T, Nishimura Y, Murata Y, Onoe H, Isa T, Kojima T (2018) Comprehensive analysis of area-specific and time-dependent changes in gene expression in the motor cortex of macaque monkeys during recovery from spinal cord injury. J Comp Neurol, 526:1110-1130.

Matsumoto M, Inoue K, Takada M (2018) Causal role of neural signals transmitted from the frontal eye field to the superior colliculus in saccade generation. Front Neural Circuits, 12:69.

Nakagawa H, Takada M (2018) Promoting functional recovery by inhibition of repulsive guidance molecule-a after spinal cord injury. Neural Regen Res, 13:981-982.

Hidaka Y, Lim CK, Takayama-Ito M, Park CH, Kimitsuki K, Shiwa N, Inoue K, Itou T (2018) Segmentation of the rabies virus genome. Virus Research, 252:68-75.

Ishida H, Inoue K, Takada M (2018) Multisynaptic projections from the amygdala to the ventral premotor cortex in macaque monkeys: Anatomical substrate for feeding behavior. Front Neuroanat, 12:3.

Amemori K, Amemori S, Gibson DJ, Graybiel AM (2018) Striatal microstimulation induces persistent and repetitive negative decision-making predicted by striatal beta-band oscillation. Neuron, 99:829-841.

Dagdeviren C, Ramadi KB, Joe P, Spencer K, Schwerdt HN, Shimazu H, Delcasso S, Amemori K, Nunez-Lopez C, Graybiel AM, Cima MJ, Langer R (2018) Miniaturized neural system for chronic, local intracerebral drug delivery. Science Translational Medicine, 10:eaan2742.

Griggs SW, Amita H, Gopal A, Hikosaka O (2018) Visual neurons in the superior colliculus discriminate many objects by their historical values. Front Neurosci, 12:396.

Ogura Y, Amita H, Matsushima T (2018) Ecological Validity of Impulsive Choice: Consequences of Profitability-Based Short-Sighted Evaluation in the Producer-Scrounger Resource Competition. Front Appl Math Stat, 4:49.


Uesaka M, Agata K, Oishi T, Nakashima K, Imamura T (2017) Evolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals. BMC Genomics, 18:285.

Galvan A, Stauffer WR, Ackerson L, El-Shamayleh Y, Inoue K, Ohayon S, Schmid M (2017) Nonhuman primate optogenetics: Recent advances and future directions. J Neurosci, 37:10894-10903.

Kobayashi K, Inoue K, Tanabe S, Kato S, Takada M, Kobayashi K (2017) Pseudotyped lentiviral vectors for retrograde gene delivery into target brain regions. Front Neuroanat, 11:65.

Ichinose H, Inoue K, Arakawa S, Watanabe Y, Kurosaki H, Koshiba S, Hustad E, Takada M, Aasly JO (2017) Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease. J Neural Transm, 125:45-52.

Oh Y-M, Karube F, Takahashi S, Kobayashi K, Takada M, Uchigashima M, Watanabe M, Nishizawa K, Kobayashi K, Fujiyama F (2017) Using a novel PV-Cre ratmodel to characterize pallidonigral cells and their terminations. BrainStruct Funct, 222:2359-2378.

Seiriki K, Kasai A, Hashimoto T, Schulze W, Niu M, Yamaguchi S, Nakazawa T, Inoue K, Uezono S, Takada M, Naka Y, Igarashi H, Tanuma M, Wascheck JA, Ago Y, Tanaka KF, Hayata-Takano A, Nagayasu K, Shintani N, Hashimoto R, Kunii Y, Hino M, Matsumoto J, Yabe H, Nagai T, Fujita K, Matsuda T, Takuma K. Baba A, Hashimoto H, (2017) High-speed and scalable whole-brain imaging in rodents and primates. Neuron, 94:1085-1100.

Tanabe S, Inoue K, Tsuge H, Uezono S, Nagaya K, Fijiwara M, Kato S, Kobayashi K, Takada M (2017) The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain. Neurosci Res, 120:45-52.

Saga Y, Nakayama Y, Inoue K,Ymagata T, Hashimoto M, Tremblay L ,Takada M,Hoshi E (2017) Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus. Eur J Neurosci, 45:1186-1199.

Friedman A, Homma D, Bloem B, Gibb LG, Amemori K, Hu D, Delcasso S,Truong TF, Yang J, Hood AS, Mikofalvy KA, Beck DW, Nguyen N, Nelson ED, Toro Arana SE, Vorder Bruegge RH, Goosens KA, Graybiel AM (2017) Chronic stress alters striosome-circuit dynamics, leading to aberrant decision-making. Cell, 171:1191-1205.

Schwerdt HN, Shimazu H, Amemori K, Amemori S, Tierney PL, Gibson DJ,Hong S, Yoshida T, Langer R, Cima MJ, Graybiel AM (2017) Long-term dopamine neurochemical monitoring in primates. Proceedings of the National Academy of Sciences, 114:13260-13265.

Hikosaka O, Ghazizadeh A, Griggs W, Amita H (2017) Parallel basal ganglia circuits for decision making. J Neural Transm, 125:515-529.

Kim HF, Amita H, Hikosaka O (2017) Indirect pathway of caudal basal ganglia for rejection of valueless visual objects. Neuron, 94:920-930.


Nagai Y, Kikuchi E, Lerchner W, Inoue K, Ji B, Eldridge MAG, Kaneko H, Kimura Y, Oh-Nishi A, Hori Y, Kato Y, Hirabayashi T, Fujimoto A, Kumata K, Zhang M-R, Aoki I, Suhara T, Higuchi M, Takada M, Richmond BJ, Minamimoto T (2016) PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation. Nat Commun, 7:13605.

Kimura K, Inoue K, Kuroiwa Y, Ynaka F, Takada M (2016) Propagated butTopologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaque. PLoS ONE, 11:e0166861.

Tsutsui-Kimura I, Ohmura Y, Izumi T, Matsushima T, Amita H, Yamaguchi T, Yoshida T, Yoshioka M (2016) Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex. Behav Brain Res, 296:361-372.


McCairn KW, Nagai Y, Hori Y, Ninomiya T, Kikuchi E, Lee J-Y, Suhara T, Iriki A, Minamimoto T, Takada M, Isoda M, Matsumoto M (2015) A primary role for nucleus accumbens and related limbic network in vocal tics. Neuron, 89:300-307.

Ishida H, Inoue K, Takada M, Hoshi E (2015) Origins of multisynaptic projections from the basal ganglia to the forelimb region of the ventral premotor cortex in macaque monkeys. Eur J Neurosci, 43:258-269.

Kawai T, Yamada H, Sato N, Takada M, Matsumoto M (2015) Roles of the lateral habenula and anterior cingulate cortex in negative outcome monitoring and behavioral adjustment in nonhuman primates. Neuron, 88:792-804.

Ito T, Inoue K, Takada M (2015) Distributions of glutamatergic, GABAergic, and glycinergic neurons in the auditory pathways of macaque monkeys. Neuroscience, 310:128-151.

Inoue K, Takada M, Matsumoto M (2015) Neuronal and behavioral modulations by pathway-selective optogenetic stimulation of the primate oculomotor system. Nat Commun, 6:8378.

Nakagawa H, Ninomiya T, Yamashita T, Takada M (2015) Reorganization of corticospinal tract fibers after spinal cord injury in adult macaques. Sci Rep 5:11986.

Chung G, Saito M, Kawano T, Lee S, Takada M, Bae Y.C, Oh S.B, Kang Y (2015) Generation of resonance-dependent oscillation by mGluR-I activation switches single spiking to bursting in mesencephalic trigeminal sensory neurons. Eur J Neurosci, 41:998-1012.

Hiraoka M, Inoue K, Senoo H, Takada M (2015) Morphological study of the accommodative apparatus in the monkey eye. Anat Rec, 298:630-636.

Murata Y, Higo N, Oishi T, Isa T (2015) Increased expression of the growth-associated protein-43 gene after primary motor cortex lesion in macaque monkeys. Neuroscience Research, 98:64-69.

Murata Y, Higo N, Hayashi T, Nishimura Y, Sugiyama Y, Oishi T, Tsukada H, Isa T, Onoe H (2015) Temporal plasticity involved in recovery from manual dexterity deficit after motor cortex lesion in macaque monkeys. Journal of Neuroscience, 35:84-95.


Oishi T, Imai H, Go Y, Imamura M, Hirai H, Takada M (2014) Sporadic premature aging in a Japanese monkey: a primate model for progeria. PLoS ONE, e111867.

Tohno Y, Tohno S, Oishi T, Minami T, Khanpetch P, Azuma C, Quiggins R (2014) Age-related decrease of the phosphorus content in the ligamentum capitis femoris of monkeys. Biological Trace Element Research, 161:78-84.

Amita H, Matsushima T (2014) Competitor suppresses neuronal representation of food reward in the nucleus accumbens/medial striatum of domestic chicks. Behav Brain Res, 268:139-149.


Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H (2013) Efficient in vivo depletion of CD8+ T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration. Immunol Lett, 154:12-17.

Hirata Y, Miyachi S, Inoue K, Ninomiya T, Takahara D, Hoshi E, Takada M (2013) Dorsal area 46 is a major target of disynaptic projections from the medial temporal lobe. Cereb Cortex, 23:2965-2975.

Hayashizaki S, Hirai S, Ito Y, Honda Y, Arime Y, Sora I, Okado H, Kodama T, Takada M (2013) Methamphetamine increases locomotion and dopamine transporter activity in dopamine D5 receptor-deficient mice. PLoS ONE, 8:e75975.

Matsumoto M, Takada M (2013) Distinct representations of cognitive and motivational signals in midbraindopamine neurons. Neuron, 79:1011-1024.

Isomura Y, Takekawa T, Harukuni R, Handa T, Aizawa H, Takada M, Fukai T (2013) Reward-modulated motor information in identified striatum neurons. J Neurosci, 33:10209-10220.

Hayakawa H, Nagai M, Kawanami A, Nakata Y, Nihira T, Ogino M, Takada M, Saido T, Takano J, Saegusa M, Mikami T, Hamada J, Nishiyama K, Mochizuki H, Mizuno Y (2013) Loss of DARPP-32 and calbindin in multiple system atrophy. J Neural Transm, 120:1689-1698.

Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T (2013) Protocadherin 17 regulates presynaptic assembly in topographic cortico-basal ganglia circuits. Neuron, 78:839-854.

Miyachi S, Hirata Y, Inoue K, Lu X, Nambu A, Takada M (2013) Multisynaptic projections from the ventrolateral prefrontal cortex to hand and mouth representations of the monkey primary motor cortex. Neurosci Res, 76:141-149.

Hiraoka M, Kuroda T, Inoue K, Senoo H, Takada M (2013) Developmental anatomy in the zonular connection with lens capsule in macaque eye. Anat Rec, 295:347-54.

Sugiyama Y, Higo N, Yoshino-Saito K, Murata Y, Nishimura Y, Oishi T, Isa T (2013) Effects of early versus late rehabilitative training on manual dexterity after corticospinal tract lesion in macaque monkeys. Journal of Neurophysiology, 109:2853-2865.

Yamamoto T, Oishi T, Higo N, Murayama S, Sato A, Takashima I, Sugiyama Y, Nishimura Y, Murata Y, Yoshino-Saito K, Isa T, Kojima T (2013) Differential Expression of Secreted Phosphoprotein 1 in the Motor Cortex among Primate Species and during Postnatal Development and Functional Recovery. PLoS ONE, 8:e65701.

Kojima T, Higo N, Sato A, Oishi T, Nishimura Y, Yamamoto T,Murata Y, Yoshino-Saito K, Onoe H, Isa T (2013) Functional annotation of genes differentially expressed between primary motor and prefrontal association cortices of macaque brain. Neurochemical Research, 38:133-140.


Ninomiya T, Sawamura H, Inoue K, Takada M (2012) Multisynaptic inputs from the medial temporal lobe to V4 in macaques PLoS ONE, 7:e52115.

Lu X, Miyachi S, Takada M (2012) Anatomical evidence for the involvement of medial cerebellar output from the interpositus nuclei in cognitive functions. Proc Natl Acad Sci USA, 109:18980-18984.

Takahara D, Inoue K, Hirata Y, Miyachi S, Nambu A, Takada M, Hoshi E (2012) Multisynaptic projections from the ventrolateral prefrontal cortex to the dorsal premotor cortex in macaques: anatomical substrate for conditional visuomotor behavior. Eur J Neurosci, 36:3365-3375.

Inoue K, Koketsu D, Kato S, Kobayashi K, Nambu A, Takada M (2012) Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic ”hyperdirect” pathway. PLoS ONE, 7:e39149.

Ninomiya T, Sawamura H, Inoue K, Takada M (2012) Segregated pathways carrying frontally derived top-down signals to visual areas MT and V4 in macaques. J Neurosci, 32:6851-6858.

Hiraoka M, Inoue K, Ninomiya T, Takada M (2012) Ischaemia in the Zinn-Haller circle and glaucomatous optic neuropathy in macaque monkeys. Br J Ophthalmol, 96:597-603.

Hiraoka M, Inoue K, Kawano H, Takada M (2012) Localization of papillofoveal bundles in primates. Anat Rec, 295:347-354.

Shimizu J, Fukuda T, Abe T, Ogihara M, Kubota J,Sasaki A, Azuma T, Sasaki K, Shimizu K, Oishi T, Umemura S-I, Furuhata H (2012) Ultrasound Safety with Midfrequency Transcranial Sonothrombolysis: Preliminary Study on Normal Macaca Monkey Brain. Ultrasound in Medicine and Biology, 38:1040-1050.

Higaki S, Takumi K, Itoh M, Watanabe G, Taya K, Shimizu K, Hayashi M, Oishi T (2012) Response of ERβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause. Neuroscience Research, 72:148-154.

Matsunami S, Ogura Y, Amita H, Izumi T, Yoshioka M, Matsushima T (2012) Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks. Behav Brain Res, 233:577-586.


Kato S, Kuramochi M, Takasumi K, Kobayashi K, Inoue K, Takahara D, Hitoshi S, Ikenaka K, Shimada T, Takada M, Kobayashi K (2011) Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein. Hum Gene Ther, 22:1511-1523.

Tachibana Y, Iwamuro H, Kita H, Takada M, Nambu A (2011) Subthalamo-pallidal interactions underlying parkinsonian neuronal oscillations in the primate basal ganglia. Eur J Neurosci, 34:1470-1484.

Masuda M, Miura M, Inoue R, Imanishi M, Saino-Saito S, Takada M, Kobayashi K, Aosaki T (2011) Postnatal development of tyrosine hydroxylase mRNA-expressing neurons in mouse neostriatum. Eur J Neurosci, 34:1355-1367.

Takara S, Hatanaka N, Takada M, Nambu A (2011) Differential activity patterns of putaminal neurons with inputs from the primary motor cortex and supplementary motor area in behaving monkeys. J Neurophysiol, 106:1203-1217.

Yasuda T, Hayakawa H, Nihira T, Ren Y-R, Nagai M, Hattori N, Miyake K, Takada M, Shimada T, Mizuno Y, Mochizuki H (2011) Parkin-mediated dopaminergic neuroprotection in an MPTP-minipump mouse model of Parkinson's disease. J Neuropath Exp Neurol, 70:686-697.

Yumoto N, Lu X, Henry T, Miyachi S, Nambu A, Fukai T, Takada M (2011) A neural correlate of the processing of multi-second time intervals in primate prefrontal cortex. PLoS ONE, 6(4): e19168.

Ninomiya T, Sawamura H, Inoue K, Takada M (2011) Differential architecture of multisynaptic geniculo-cortical pathways to V4 and MT. Cereb Cortex, 21:2797-2808.

Matsumoto M, Hikosaka O (2011) Electrical stimulation of the primate lateral habenula suppresses saccadic eye movement through a learning mechanism. PLoS ONE, 6: e26701.

Kato S, Kobayashi K, Inoue K, Kuramochi M, Okada T, Yaginuma H, Morimoto K, Shimada T, Takada M, Kobayashi K (2011) A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein. Hum Gene Ther, 22(2):197-206.

Saga M, Hirata Y, Takahara D, Inoue K, Miyachi S, Nambu A, Tanji J, Takada M, Hoshi E (2011) Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques. Eur. J. Neurosci, 33(2):285-297.

Iwata K, Miyachi S, Imanishi M, Tsuboi Y, Kitagawa J, Teramoto K, Hitomi S, Shinoda M, Kondo M, Takada M (2011) Ascending multisynaptic pathways from the trigeminal ganglion to the anterior cingulate cortex. Exp. Neurol, 227(1):69-78.

Tohno Y, Tohno S, Satoh H, Hayashi M, Oishi T, Minami T, Mahakkanukrauh P (2011) Gender differences in the phosphorus content of the sino-atrial nodes and other cardiac regions of monkeys. Biological Trace Element Research, 143,2,871-881.

Nagano M, Oishi T, Suzuki H (2011) Distribution and pharmacological characterization of primate NK-2 tachykinin receptor in the central nervous system of the rhesus monkey. Neuroscience Letters, 503,1,23-26.

Shinomiya K, Matsuda K, Oishi T, Otsuna H, Ito K (2011) Flybrain neuron database: A comprehensive database system of the Drosophila brain neurons. Journal of Comparative Neurology, 519,5,807-833.

Yamamoto T, Higo N, Sato A, Nishimura Y, Oishi T, Murata Y, Yoshino-Saito K, Isa T, Kojima T (2011) SPP1 expression in spinal motor neurons of the macaque monkey. Neuroscience Research, 69,1,81-86.

Amita H, Matsushima T (2011) Instantaneous and cumulative influences of competition on impulsive choices in domestic chicks. Front Neurosci, 5:101.


Fujiwara-Tsukamoto Y, Isomura Y, Imanishi M, Ninomiya T, Tsukada M, Yanagawa Y, Fukai T, Takada M (2010) Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons. J. Neurosci, 30:13679-13689.

Toyoda H, Saito M, Okazawa M, Hirao K, Sato H, Abe H, Takada K, Funabiki K, Takada M, Kaneko T, Kang Y (2010) Protein kinase G dynamically modulates TASK1-mediated leak K+ currents in cholinergic neurons of the basal forebrain. J. Neurosci, 30:5677-5689.

Hashimoto M, Takahara D, Hirata Y, Inoue K, Miyachi S, Nambu A, Tanji J, Takada M, Hoshi E (2010) Motor and nonmotor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques. Eur. J. Neurosci, 31(8):1402-1413.

Higo N, Sato A, Yamamoto T, Nishimura Y, Oishi T, Murata Y, Onoe H, Yoshino-Saito K, Tsuboi F, Takahashi M, Isa T, Kojima T (2010) SPP1 is expressed in corticospinal neurons of the macaque sensorimotor cortex. Journal of Comparative Neurology, 518(13):2633-2644.

Satoh H, Tohno S, Minami T, Oishi T, Hayashi M, Tohno Y (2010) Gender-related differences in a process of the age-dependent alterations of the elements in monkey sino-atrial node. Korean Journal of Physiology & Pharmacology, 14(5):249-256.

Yoshino-Saito K, Nishimura Y, Oishi T, Isa T (2010) Quantitative inter-segmental and inter-laminar comparison of corticospinal projections from the forelimb area of the primary motor cortex of macaque monkeys. Neuroscience, 171(4):1164-1179.

Kaoru T, Liu FC, Ishida M, Oishi T, Hayashi M, Kitagawa M, Shimoda K, Takahashi H (2010) Molecular characterization of the intercalated cell masses of the amygdala: implications for the relationship with the striatum. Neuroscience, 166(1):220-230.

Tohno Y, Suwanahoy P, Tohno S, Sinthubua A, Azuma C, Nishiwaki F, Moriwake Y, Kumai T, Minami T, Laowatthanaphong S, Mahakkanukrauh P, Oishi T, Hayashi M (2010) Age-related changes of elements in the tendons of the peroneus longus muscles in Thai, Japanese, and monkeys. Biol Trace Elem Res, 133(3):291-303.

Ohira K, Furuta T, Hioki H, Nakamura KC, Kuramoto E, Tanaka Y, Funatsu N, Shimizu K, Oishi T, Hayashi M, Miyakawa T, Kaneko T, Nakamura S (2010) Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells. Nat Neurosci, 13(2):173-179.

Bromberg-Martin ES, Matsumoto M, Nakahara H, Hikosaka O (2010) Multiple timescales of memory in lateral habenula and dopamine neurons. Neuron, 67(3):499-510.

Bromberg-Martin ES, Matsumoto M, Hikosaka O (2010) Distinct tonic and phasic anticipatory activity in lateral habenula and dopamine neurons. Neuron, 67(1):144-155.

Bromberg-Martin ES, Matsumoto M, Hong S, Hikosaka O (2010) A pallidus-habenula-dopamine pathway signals inferred stimulus values. Journal of Neurophysiology, 104:1068-1076.

Amita H, Kawamori A, Matsushima T (2010) Social influences of competition on impulsive choices in domestic chicks. Biol Lett, 6:183-186.